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KMID : 1007520070160040641
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Food Science and Biotechnology
2007 Volume.16 No. 4 p.641 ~ p.645
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Anti-Proliferative and Anti-Carcinogenic Enzyme-inducing Activities of Delphinidin in Hepatoma Cells
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Jang Chan-Ho
Lee In-Ae
Lim Hyun-Ae
Kim Ju-Ryoung
Ha Young-Ran
Yu Hoon
Sung Mi-Kyung
Kim Jeong-Sang
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Abstract
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Delphinidin, an aglycone form of anthocyanins, was demonstrated to have anti-carcinogenic potential. The compound at 50 μg/mL caused a significant increase of quinone reductase activity, an anti-carcinogenic marker enzyme, in mouse hepatoma cell lines (Hepa1c1c7 and BPRc1). Delphinidin enhanced the expression of other detoxifying or antioxidant enzymes including glutathione S-transferase, gamma-glutamylcysteine synthetase, heme oxygenase 1, and glutathione reductase. It suppressed the proliferation of murine hepatoma cells in a dose-dependent manner, with approximately IC50 of 70 μg/mL. These results suggest that delphinidin might be useful for cancer prevention.
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KEYWORD
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delphinidin, antioxidant, cancer prevention, quinone reductase
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